|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patients with metastatic high-grade (WHO G3) gastroenteropancreatic neuroendocrine neoplasms (NET G3 and NEC) represent a heterogeneous subgroup with poor prognosis and standard platinum-etoposide chemotherapy has limited therapeutic benefit.
|
31846429 |
2020 |
|
Venous Thromboembolism
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In pancreatic cancer patients, elevated levels of plasma EVTF activity and citrullinated histone H3 (H3Cit), a NET biomarker, are independently associated with VTE.
|
31808871 |
2019 |
|
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall our findings demonstrate the pathophysiological involvement of NET availability in adult ADHD.
|
31732713 |
2019 |
|
Adult attention deficit hyperactivity disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[<sup>11</sup>C]methylreboxetine positron emission tomography study.
|
31732713 |
2019 |
|
Malignant neoplasm of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
Lung NET account for ~1%-2% of all lung malignancies in adults and 30% of all NETs.
|
31712234 |
2019 |
|
Parkinson Disease
|
0.060 |
Biomarker
|
disease |
BEFREE |
Altogether, our findings raise the hypothesis that concomitant modulation of µ-opioid receptor and norepinephrine transporter might constitute relevant intervention strategies in PD and that tapentadol holds therapeutic potential that may be translated into the clinical practice.
|
31682948 |
2020 |
|
Lupus Erythematosus, Systemic
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that a large number of the autoepitopes of NET proteins that are recognized by autoantibodies produced by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients are also removed by the proteases.
|
31661552 |
2020 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that a large number of the autoepitopes of NET proteins that are recognized by autoantibodies produced by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients are also removed by the proteases.
|
31661552 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mice treated with NET-1 siRNA-conjugated TNB showed a significant decrease in tumor growth and the highest survival rate.
|
31657628 |
2019 |
|
Malignant Head and Neck Neoplasm
|
0.030 |
Biomarker
|
disease |
BEFREE |
Correction to: Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank.
|
31640611 |
2019 |
|
Head and Neck Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Correction to: Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank.
|
31640611 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.040 |
Biomarker
|
disease |
BEFREE |
Quantitative Pretreatment CT Parameters as Predictors of Tumor Response of NET Liver Metastasis to TAE.
|
31639795 |
2019 |
|
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to examine whether the SLC6A2 rs36011 (T)/rs1566652 (G) haplotype affected the intrinsic brain activity in children with ADHD and whether these gene-brain modulations were associated with visual memory and attention in this population.
|
31595036 |
2019 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeting platelet IP6K1 might useful to decrease NET-dependent pancreatic tissue inflammation and tissue injury in patients with AP.
|
31593553 |
2019 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that combining strong NET and weak DAT inhibition could lead to the development of a highly effective cognitive enhancer that lacks the potential for addiction.
|
31580915 |
2020 |
|
Neuroendocrine Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Appendiceal carcinoid (neuroendocrine tumor or NET) is a rare neuroendocrine neoplasm often found incidentally following appendectomy for appendicitis.
|
31555859 |
2019 |
|
Appendicitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Appendiceal carcinoid (neuroendocrine tumor or NET) is a rare neuroendocrine neoplasm often found incidentally following appendectomy for appendicitis.
|
31555859 |
2019 |
|
Neutrophilia (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin-1β (IL-1β) modulates the expression of granulocyte colony-stimulating factor (G-CSF), a cytokine that promotes cancer-associated neutrophilia and NET generation.
|
31552036 |
2019 |
|
Malnutrition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Malnutrition and dietary modification amongst patients with GEP NET is more prevalent than initially thought: up to 25% of in-patients with GEP NET are malnourished.
|
31550712 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, TNBS conjugated with NET-1 siRNA inhibited tumor growth and prolonged the life of experimental animals.
|
31544556 |
2019 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of therapeutic effect of targeting nanobubbles conjugated with NET-1 siRNA by shear wave elastography: an <i>in vivo</i> study of hepatocellular carcinoma bearing mice model.
|
31544556 |
2019 |
|
Syncope
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Pharmacological norepinephrine transporter (NET) inhibition increases sympathetic tone and decreases tilt-induced syncope in healthy subjects.
|
31538180 |
2019 |
|
Reflex bradycardia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Norepinephrine transporter inhibition significantly decreased the risk of tilt-induced syncope in VVS subjects, mainly by blunting reflex bradycardia, thereby preventing final falls in cardiac index and BP.
|
31538180 |
2019 |
|
Familial neurocardiogenic syncope
|
0.010 |
Biomarker
|
disease |
BEFREE |
Norepinephrine transporter inhibition significantly decreased the risk of tilt-induced syncope in VVS subjects, mainly by blunting reflex bradycardia, thereby preventing final falls in cardiac index and BP.
|
31538180 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GEP-NET primary tumor location or secretory syndrome did not influence the risk for MetS.
|
31533348 |
2019 |